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ea0022p119 | Bone/Calcium | ECE2010

PTH treatment in adult hypophosphatasia: significant increase in S-AP, improvement of pain and fracture healing in two siblings with ALPL gene mutations G339R and E191K

Schalin-Jantti Camilla , Valimaki Matti , Mornet Etienne

Background: Hypophosphatasia (HPP) is characterized by low serum alkaline phosphatase (S-AP) activity due to loss-of function mutations in the ALPL gene. A hallmark of adult HPP is painful, slowly healing metatarsal and femur stress fractures. There is no treatment for the disease but beneficial effects of parathyroid hormone (PTH) treatment was previously demonstrated in one patient. It is unclear how parathyroid hormone (PTH) can stimulate S-AP despite loss-of functio...

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ea0041ep138 | Calcium and Vitamin D metabolism | ECE2016

Increasing incidence of parathyroid carcinoma – a nationwide study

Ryhanen Eeva M , Leijon Helena , Metso Saara , Eloranta Eija , Korsoff Pirkko , Niskanen Leo , Ahtiainen Petteri , Kekalainen Paivi , Tamminen Marjo , Ristamaki Raija , Knutar Otto , Loyttyniemi Eliisa , Heiskanen Ilkka , Valimaki Matti J. , Haglund Caj , Arola Johanna , Schalin-Jantti Camilla

Introduction and design: Parathyroid carcinoma (PC) is a rare endocrine malignancy and the diagnosis is difficult. As the incidence seems to be increasing, we examined all cases diagnosed in our country during years 20002011 and compared the results to those of atypical parathyroid (AA; n=28) and parathyroid adenomas (A; n=72). All tissue specimens were re-examined.Results: In 20002011, 32 patients were diagnosed with PC in ...

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Endocrine Abstracts

PTH treatment in adult hypophosphatasia: significant increase in S-AP, improvement of pain and fracture healing in two siblings with ALPL gene mutations G339R and E191K

Increasing incidence of parathyroid carcinoma – a nationwide study

BiosciAbstracts